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March 2012 - Volume 6, Issue 3

 

In this issue...

-   Office workers gain energy when given vitamin C at work

-   Supplement cocktail in randomized trial made trauma wounds heal twice as fast

-   Vitamin D and K deficiencies are common in patients with bowel disease

-   Clinical trial of B12 supplements show they improve cognitive function  and 1 in 20 is deficient

-   Omega 3s are effective in treating bipolar depression, but not mania

-   New research sheds light on the role of manganese in tumor suppressor gene

 

In SpectraCell News...

PRESS RELEASE: SpectraCell Now Measures Manganese.  Read more...

PRESS RELEASE: SpectraCell Introduces Immunidex.  Read more...

                                                                                                                                                 

 

 

 

CLINICAL UPDATE - OFFICE WORKERS GAIN ENERGY WHEN GIVEN VITAMIN C AT WORK

A double-blind randomized trial on 141 healthy volunteers aged 20 to 49 years old was performed in which one group received 10 grams of vitamin C intravenously while a placebo group received saline intravenously.  Fatigue scores, oxidative stress and plasma vitamin C and side effects were all measured.  Fatigue levels, at two hours and one day post supplementation,  were significantly reduced in the group receiving vitamin C, especially in those whose initial vitamin C levels were particularly low.  No major side effects were reported in either group.

(Nutrition Journal, January 2012)

LINK to ABSTRACT  Intravenous vitamin C administration reduces fatigue in office workers: a double-blind randomized controlled trial.

LINK to FREE FULL TEXT 

 

 

 

 

 

CLINICAL UPDATE - SUPPLEMENT COCKTAIL IN RANDOMIZED TRIAL MADE TRAUMA WOUNDS HEAL TWICE AS FAST

In a randomized, double-blind, placebo-controlled trial, 20 trauma patients were given oral antioxidants (vitamin A, C, E, zinc, selenium and glutamine ) or placebo for two weeks.  Time to wound closure in the supplemented group was five weeks while it took 10 weeks for wound closure to occur in the placebo group.  Interestingly, the authors noted that “despite normal plasma levels, intracellular deprivation may occur,” indicating that intracellular measures of nutrients were more clinically relevant that serum levels.

(Clinical Nutrition, January 2012)

LINK to ABSTRACT Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: A PRCT.

 

 

 

 

CLINICAL UPDATE - VITAMIN D AND K DEFICIENCIES ARE COMMON IN PATIENTS WITH BOWEL DISEASE

Bone mineral density and levels of vitamin D and K, both of which play a vital role in bone development, were measured in 87 patients that had either Crohn’s disease or ulcerative colitis.  Researchers found that bone vitamin K was insufficient in patients with Crohn’s disease and the low levels contributed to the inflammatory process of Crohn’s disease.  Levels of vitamin D were also lower in patients with low bone density when compared to healthy controls.

(Nutrition, October 2011)

LINK to ABSTRACT Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease.

 

 

 

 

CLINICAL UPDATE - CLINICAL TRIAL OF B12 SUPPLEMENTS SHOW THEY IMPROVE COGNITIVE FUNCTION; 1 IN 20 I DEFICIENT

A randomized controlled trial was performed on 900 elderly adults with depressive symptoms.  The participants were given 400μg of folic acid and 100μg of vitamin B12 daily for two years.  Cognitive function was evaluated at one year and two years.  Researchers found an improvement in memory performance after two years of supplementation when compared to placebo.  In a different study, almost 5% of a group of 5600 people of all ages were found to be deficient in B12.

(American Journal of Clinical Nutrition, January 2012)

(American Journal of Clinical Nutrition, October 2011)

LINK to ABSTRACT Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with depressive symptoms--the Beyond Ageing Project: a randomized controlled trial.

LINK to ABSTRACT Vitamin B-12 and homocysteine status in a folate-replete population: results from the Canadian Health Measures Survey.

 

 

 

 

 

CLINICAL UPDATE - OMEGA 3S ARE EFFECTIVE IN TREATING BIPOLAR DEPRESSION, BUT NOT MANIA

A meta-analysis on the clinical administration of omega 3 fatty acids specifically for treatment of bipolar depression and bipolar mania provided strong evidence that omega 3s were effective in mitigating the symptoms of depression.  Interestingly, the meta-analysis, which included five studies with 291 total bipolar patients, did not show any benefit of omega 3 fatty acids in treating bipolar mania.

(Journal of Clinical Psychiatry, January 2012)

LINK to ABSTRACT Omega-3 for bipolar disorder: meta-analyses of use in mania and bipolar depression.

 

 

 

 

CLINICAL UPDATE - NEW RESEARCH SHEDS LIGHT ON THE ROLE OF MANGANESE IN TUMOR SUPPRESSOR GENE

Interesting animal research on the powerful antioxidant manganese superoxide dismutase shows that this antioxidant is controlled by a gene (p53) that actually switches on or off, depending on the stage of cancer – it turns off in early tumor growth and turns on in late stages of cancer.

(Cancer Research, November 2011)

LINK to ABSTRACT Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages.