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December 2011 - Volume 5, Issue 12

 

In this issue...

- Vitamin E triggers gene that kills breast cancer cells

- Can omega 3 index be used to diagnose sleep apnea?

- Vitamin B5 lowers LDL cholesterol

- Correcting glutathione deficiency reduces signs of aging

- Cysteine supplements reduce muscle fatigue after exercise

- Supplements that promote heart function also help erectile dysfunction

 

                                                                                                                                                 

 

 

 

CLINICAL UPDATE - VITAMIN E TRIGGERS GENE THAT KILLS BREAST CANCER CELLS

Researchers uncovered a unique mechanism of action of the vitamin E form gamma-tocotrienol on breast cancer cells.  Specifically, the gamma-tocotrienols (one of eight biologically active forms of vitamin E), triggered a gene that causes cell death to cancerous, but not healthy cells in breast tissue.  This discovery lends further credence to the argument that the recently published results of the SELECT (Selenium and Vitamin E Cancer Prevention Trial)  trial are not valid because in that trial, only supplements of alpha-tocopherol  were given, which many argue caused a deficiency in gamma-tocotrienol.

(Journal of Nutritional Biochemistry, January 2012)

LINK to ABSTRACT Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells.

 

 

 

 

CLINICAL UPDATE - CAN OMEGA 3 INDEX BE USED TO DIAGNOSE SLEEP APNEA?

The level of the omega 3 fatty acid DHA (docosahexaenoic acid) in the red blood cells of 350 people who were undergoing sleep analysis was measured.  Researchers found that the severity of sleep apnea was inversely related to a patient’s omega 3 index, suggesting that DHA’s role in neural tissue might play a role in autonomic sleep functions.

(Journal of Clinical Sleep Medicine, August 2011)

LINK to ABSTRACT Membrane level of omega-3 docosahexaenoic acid is associated with severity of obstructive sleep apnea.

 

 

 

 

 

CLINICAL UPDATE - VITAMIN b5 LOWERS LDL CHOLESTEROL

120 people were divided into two groups: 60 received 600mg per day of pantethine (a form of vitamin B5) for eight weeks when the dosage was then increased to 900mg per day for another eight weeks and the other 60 people received identically labelled placebo pills.  Both groups followed the same lifestyle changes during the trial.  At the end of four months, only the supplemented group had about 5% lower LDL (low density lipoprotein) cholesterol and apolipoprotein B.  Authors of the study emphasized that for every 1 mg/dL reduction in LDL, there is a 1% reduction in overall cardiovascular risk.

(Nutrition Research, August 2011)

LINK to ABSTRACT Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation.

 

 

 

CLINICAL UPDATE - CORRECTING GLUTATHIONE DEFICIENCY REDUCES SIGNS OF AGING

When a group of elderly people were compared to a younger group, the levels of glutathione were much lower and markers of oxidative stress such as isoprostanes were much higher in the elderly group, which was expected.  But interestingly, once the elderly group was supplemented with dietary cysteine and glycine (precursors to glutathione synthesis) for two weeks, the differences listed above were no longer observed – the supplemented elderly and unsupplemented younger groups has the same levels of oxidative stress and glutathione concentrations.

(American Journal of Clinical Nutrition, September 2011)

LINK to ABSTRACT Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation.

 

 

 

 

CLINICAL UPDATE - CYSTEINE SUPPLEMENTS REDUCE MUSCLE FATIGUE AFTER EXERCISE

Short term supplementation of 1200 mg of N-acetyl-cysteine for seven days significantly improved muscle endurance (reduced muscle fatigue), increased maximum oxygen consumption (VO2max) in a group of sedentary men.

(Oxidative Medicine and Cellular Longevity, 2011)

LINK to ABSTRACT N-acetylcysteine supplementation controls total antioxidant capacity, creatine kinase, lactate, and tumor necrotic factor-alpha against oxidative stress induced by graded exercise in sedentary men.

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CLINICAL UPDATE - SUPPLEMENTS THAT PROMOTE HEART FUNCTION ALSO HELP ERECTILE DYSFUNCTION

In a small study, 54 men were given propionyl-L-carnitne, L-arginine and vitamin B3 (niacin) for three months.  Sexual function improved in 77% of the enrolled subjects, suggesting that nutraceutical treatment for erectile dysfunction may be feasible.

(Andrologia, October 2011)

LINK to ABSTRACT Propionyl-L-carnitine, L-arginine and niacin in sexual medicine: a nutraceutical approach for erectile dysfunction.