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May 2011 - Volume 5, Issue 05


In this issue...

- Telomerase activity predicts response to antidepressants

- Scientists recommend maternal DHA of 8% for optimal infant development

- CoQ10 minimizes toxic effects of cancer treatment

- Vitamin C lowers blood pressure

- Correcting a B2 deficiency improves iron status

- Vitamin D may alter lipoprotein size


In SpectraCell News...

- SpectraCell Now Offers LPP Cardiovascular Testing in New York.  Read more...






CLINICAL UPDATE - telomerase activity predicts response to antidepressants

The telomere lengthening, anti-aging enzyme telomerase was measured in 20 depressed but medication-free individuals and 18 controls.  After treatment with the antidepressant sertraline for 8 weeks, researchers concluded two things: (1) telomerase activity was directly related to the incidence and severity of depression and (2) in the depressed group, those with lower initial telomerase activity responded better to antidepressants.

(Molecular Psychiatry, January 2011)

LINK to ABSTRACT Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response.





CLINICAL UPDATE - Scientists recommend maternal DHA of 8% for optimal infant development

Researchers found that when red blood cells contain 8% of the omega 3 fatty acid DHA (docosahexaenoic acid), they reach a state of equilibrium that is optimal for infant neurodevelopment.  Interestingly, this is similar to the recommended omega 3 index of 8% - a sum of the omega 3 acids DHA and EPA (eicosapentaenoic acid), which reduces sudden death from cardiovascular disease by an astounding 90%.

(Journal of Nutrition, March 2011)

LINK to ABSTRACT Maternal DHA Equilibrium during Pregnancy and Lactation Is Reached at an Erythrocyte DHA Content of 8 g/100 g Fatty Acids.





CLINICAL UPDATE - CoQ10 minimizes toxic effect of cancer treatment

In vitro experiments were designed to assess how treatment with coenzyme Q10 and N-acetyl-L-cysteine would affect intracellular levels of oxidative stress in a breast cancer cell line.  Results showed that both antioxidants minimized the formation of free radicals in a dose dependent manner.

(Nutrition Journal, November 2010)

LINK to ABSTRACTExogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell line as a breast cancer cellular model.






CLINICAL UPDATE - vitamin C lowers blood pressure

In a study on men between the ages of 18 and 24 years that were divided into two groups – lean and obese – it was found that the obese men had impaired blood vessel dilation compared to the lean group and also that the obese men had only half as much vitamin C intake and 38% lower plasma levels of vitamin C.   In a different study, a double-blind randomized trial showed that supplementation with 500mg vitamin C for 45 days reduced mean blood pressure in a group of obese children, while a placebo group did not show decreases in blood pressure.

(Journal of the American Dietetic Association, May 2011)
(Brazilian Archives of Cardiology, May 2011)

LINK to ABSTRACT Vitamin C status is related to proinflammatory responses and impaired vascular endothelial function in healthy, college-aged lean and obese men.

LINK to ABSTRACT Vitamin C restores blood pressure and vasodilator response during mental stress in obese children.






CLINICAL UPDATE - correcting a b2 deficiency improves iron status

A group of women (119 total) that had a functional vitamin B2 (riboflavin) deficiency were given either 2g or 4g of vitamin B2 or placebo for eight weeks. In the supplemented but not placebo group, there was a significant increase in hemoglobin status, even though no changes were made to iron intake either  through supplements or food during that time, indicating an important role for riboflavin in the absorption of iron.

(American Journal of Clinical Nutrition, June 2011)

LINK to ABSTRACT Correcting a marginal riboflavin deficiency improves hematologic status in young women in the United Kingdom (RIBOFEM). 






CLINICAL UPDATE - vitamin d may alter lipoprotein size

In a study of 78 women between the ages of 48 and 64, it was found that higher levels of vitamin D were associated with larger HDL particles.  The researchers concluded that vitamin D may protect against cardiovascular risk by promoting large HDL particles, which are healthier than smaller HDL particles, and assisting in the transport of cholesterol from tissues back to the liver.

(Journal of Clinical Lipidology, April 2010)

LINK to ABSTRACT Vitamin D is associated with atheroprotective high-density lipoprotein profile in postmenopausal women.