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April 2011 - Volume 5, Issue 04


In this issue...

- High dose omega 3s lower triglycerides

- Study shows vitamin A lowers all cause mortality

- CoQ10 prevents hearing loss

- Vitamin B12 deficiency associated with chronic cough

- Low vitamin D linked to heart failure






CLINICAL UPDATE - High dose omega 3s lower triglycerides

In a placebo-controlled, double-blind, randomized trial, 26 adults with moderately elevated triglycerides (between 150-500 mg/dL) were given either 0.85 or 3.4 grams per day of the omega 3 fatty acids EPA and DHA for eight weeks.  The higher dosage lowered triglycerides by 27% compared to placebo.  No effect on triglycerides was seen at the lower dose.  Neither dosage of omega 3 fatty acids had any effect on markers of inflammation or endothelial function.

(American Journal of Clinical Nutrition, February 2011)

Link to ABSTRACT: Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia.







CLINICAL UPDATE - study shows vitamin a lowers all cause mortality

A survey of over 15,000 adults showed that people with the highest levels of carotenes had about 60% less risk of death from any cause than those with lower levels of vitamin A.  When vitamin A status was  categorized into four groups from highest to lowest, the risk of death from any cause got progressively lower, even after lifestyle and demographics were taken into account.

(Archives of Internal Medicine, March 2011)

Link to ABSTRACT: Serum {alpha}-Carotene Concentrations and Risk of Death Among US Adults: The Third National Health and Nutrition Examination Survey Follow-up Study.






Clinical Update - Coq10 prevents hearing loss

One study on sixty patients with age-related hearing loss showed an improvement in auditory ability in those supplemented with coenzyme Q10 versus placebo or vitamin E.  In another study, 120 hearing-impaired patients were given either coQ10 or steroids.  Hearing improved in about 75% of the patients of both groups but the coQ10 group had significantly higher speech benefits.

(Acta Otolaryngologica, May 2011)

(Clinical Otolaryngology, December 2010)

LINK to ABSTRACT Water-soluble coenzyme Q10 formulation in presbycusis: long-term effects.

LINK to ABSTRACT  Coenzyme Q10 in combination with steroid therapy for treatment of sudden sensorineural hearing loss: a controlled prospective study.





Clinical update - Vitamin B12 deficiency associated with chronic cough

Forty-two patients with chronic, unexplained cough were given intramuscular injections of vitamin B12 for two months.  The vitamin B12 deficient patients had a statistically significant increase in cough parameters (bronchial threshold, etc) than those with normal B12 levels. The study supports researchers’ theory that vitamin B12 deficiency in chronic cough acts via the same mechanism as its well-documented role in neuropathies.

(American Journal of Clinical Nutrition, March 2011)

Link to ABSTRACT:  Unexplained chronic cough and vitamin B-12 deficiency.





Clinical update - low vitamin D linked to heart failure

Vitamin D levels were measured in ninety patients with chronic heart failure and thirty-one control patients  without heart disease. Vitamin D levels were much lower in those with heart failure than controls.  Specifically, an astounding 98% of the patients with heart failure had a vitamin D deficiency defined by vitamin D levels below 75 nmol/L and severe deficiency (less than 25 nmol/L) occurred in 67% of the patients.  These results mimic observations seen in animal studies that demonstrated vitamin D supplementation can prevent heart failure in rats.
              (Nutrition, Metabolism and Cardiovascular Diseases, November2010)

Link to ABSTRACT:  High prevalence of vitamin D deficiency and its association with left ventricular dilation: an echocardiography study in elderly patients with chronic heart failure.

Link to ABSTRACT: Vitamin D deficiency in the spontaneously hypertensive heart failure [SHHF] prone rat.

Link to ABSTRACT: Should vitamin D status be assessed in patients with congestive heart failure?