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March 2011 - Volume 5, Issue 03


In this issue...

- CoQ10 lowers cholesterol via gene expression

- Omega 3 fats counteract aging by building muscle

- Selenium may lower prostate cancer markers

- Vitamin D protects against urinary tract infections

- Low maternal vitamin B12 associated with excessive infant crying

- Vitamin A suppresses insulin resistance genes






CLINICAL UPDATE - CoQ10 lowers cholesterol via gene expression

Fifty-three healthy men were given 150mg of coenzyme Q10 daily for two weeks which lowered their LDL cholesterol by over 12%.  Specifically, a decrease in the atherogenic small, dense LDL cholesterol particles was seen.  Researchers commented on the mechanism of the LDL changes, citing that the coQ10 favorably altered expression of genes involved in inflammation and cholesterol regulation.

(International Union of Biochemistry and Molecular Biology, January 2011)

Link to ABSTRACT: Ubiquinol-induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans.





CLINICAL UPDATE - omega 3 fats counteract aging by building muscle

In a trial on sixteen healthy, older adults, muscle protein synthesis was measured before and after 8 weeks of supplementation with omega 3 fats.  When compared to a group that was given a placebo of corn oil, the rate of muscle synthesis was higher in the omega 3 fat group, causing researchers to conclude that omega 3 fats might be helpful in prevention and treatment of sarcopenia (muscle loss due to aging). In a similar study, 6 weeks of fish oil supplements increased lean body mass in men and women which correlated with a reduction in fat-promoting cortisol levels.

(American Journal of Clinical Nutrition, February2011)

(Journal of the International Society of Sports Nutrition, October 2010)

Link to ABSTRACT: Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial.
Link to ABSTRACT: Effects of supplemental fish oil on resting metabolic rate, body composition, and salivary cortisol in healthy adults.  Link to FREE FULL TEXT





CLINICAL UPDATE - selenium may lower prostate cancer markers

Supplementation with selenium glycinate may increase the activities of related plasma enzymes, and reduce the levels of an important marker for the risk of prostate cancer, according to a new study that contradicts current thinking.

(Nutrition Research, February 2011)


Link to ABSTRACT: Selenium glycinate supplementation increases blood glutathione peroxidase activities and decreases prostate-specific antigen readings in middle-aged US men.





CLINICAL UPDATE - vitamin d protects against urinary tract infections

After three months of treatment with vitamin D, bladder cells of postmenopausal women exerted an increased antibacterial effect against E.coli bacteria.  Specifically, vitamin D increased the production of an antimicrobial peptide called cathelicidin, which is secreted by bladder epithelial cells to protect against urinary tract infections.

(PLoS One, December 2010)

Link to ABSTRACT:  Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder.





CLINICAL UPDATE - low maternal vitamin b12 associated with excessive infant crying

In a study in the Netherlands on over 8200 women, blood samples of B12 and folate were measured around the 12th week of pregnancy.  Lower maternal B12 status during pregnancy was associated with excessive infant crying defined as crying for more than 3 hours per day.  This association was not seen with folate levels.

(Early Human Development, February 2011)

Link to ABSTRACT: Maternal vitamin B-12 and folate status during pregnancy and excessive infant crying.





CLINICAL UPDATE - vitamin a suppresses insulin resistance genes

In vitro experiments demonstrated that beta carotene enhanced the expression of genes related to insulin sensitivity.  Specifically, when adipocytes (fat cells) were treated with beta carotene, levels of adiponectin, glucose transporter-4 and other beneficial enzymes increased, ultimately enhancing sensitivity to insulin in fat cells.

(Nutrition, December2010)

Link to ABSTRACT: β-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of reactive oxygen species and the suppression of genes related to insulin sensitivity induced by tumor necrosis factor-α.