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January 2011 - Volume 5, Issue 01


In this issue...

- Vitamin D3 is more potent than D2

- Omega 3 structure may affect bioavailability

- Zinc deficiency contributes to mood disorders

- Compound in red wine increases fat burning hormone

- Is oral health a matter of nutrition?

- Vitamin D increases testosterone levels





CLINICAL UPDATE - Vitamin D3 is more potent than D2

Vitamin D3 is 87% more potent at raising blood levels of the vitamin than D2, according to a new study from the US.  However, the D3 versus D2 debate continues since this contradicts conclusions from a 2008 study in the same journal

(Journal of Clinical Endocrinology and Metabolism, December 2010 & March 2008)

Link to NEWS SUMMARY of 2010 STUDY
Link to ABSTRACT: Vitamin D3 is more potent than vitamin D2 in humans. 

Link to NEWS SUMMARY of 2008 STUDY

Link to ABSTRACT: Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D.

Link to FREE FULL TEXT of 2008 STUDY





CLINICAL UPDATE - omega 3 structure may affect bioavailability

The type of omega-3 we take may have a distinct effect on how much is actually absorbed, according to new research

(European Journal of Lipid Science and Technology, 2010)


Link to ABSTRACT: Intestinal digestion of fish oils and ω-3 concentrates under in vitro conditions




Clinical Update - zinc deficiency contributes to mood disorders

In this comprehensive review, data indicates that zinc deficiency can induce depressive and anxiety-like behavior and that zinc supplementation improves the efficacy of some anti-depressant drugs.

(Current Opinion in Clinical Nutrition and Metabolic Care, November 2010)
LINK to ABSTRACT Role of zinc in the development and treatment of mood disorders.




Clinical update - compound in red wine increases fat burning hormone

In vitro studies demonstrated that the antioxidant resveratrol, which is found in red wine, peanuts and some berries can increase levels of the hormone adiponectin, which regulates metabolism to promote fat-burning versus fat-storage.

(Journal of Biological Chemistry, January 2011)

Link to ABSTRACT: Up-regulation of Adiponectin by resveratrol: the essential roles of the Akt/FOXO1 and AMP-activated protein kinase signaling pathways and DsbA-L.




Clinical update - is oral health a matter of nutrition?

One year of calcium and vitamin D supplementation had a small effect on oral health in a small US cohort study but a larger study on pregnant women confirmed that vitamin D deficiency is associated with periodontal disease during pregnancy.  In another randomized controlled trial, children whose mothers received calcium supplementation during pregnancy had a significant reduction in dental caries at 12 years of age.  Finally, researchers took dental exams of over 9100 adults who also participated in the National Health and Nutrition Examination Survey and concluded that higher dietary intakes of the omega 3 fat, DHA was associated with lower rates of periodontitis, leading to the conclusion that nutrient levels profoundly impact oral health.

(Journal of Peridontology, January 2011) & September 2010)

(Scandinavian Association of Obstetricians and Gynaecologists, November 2010)

(Journal of the American Dietetic Association, November 2010)

Link to ABSTRACT: One-year Effects of Vitamin D and Calcium Supplementation on Chronic Periodontitis.

Link to ABSTRACT: Vitamin D Status and Periodontal Disease Among Pregnant Women

Link to ABSTRACT: Maternal calcium supplementation during pregnancy and dental caries of children at 12 years of age: follow-up of a randomized controlled trial.

Link to ABSTRACT: n-3 fatty acids and peridontitis in US adults.






Clinical update - vitamin d increases testosterone levels

A group of men were given 3332 IU of vitamin D for one year and compared to a group of men receiving placebo.  Both bioactive and free testosterone levels of the supplemented group increased significantly while there was no difference in either vitamin D or testosterone levels in the placebo group.

            (Hormone and Metabolic Research, December 2010)

Link to ABSTRACT: Effect of Vitamin D Supplementation on Testosterone Levels in Men