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October 2010 - Volume 4, Issue 10


In this issue...

- Low magnesium associated with sudden cardiac death

- Mechanism behind choline's effect on behavior explored

- Is intravenous vitamin C safe?

- Hormonal contraception lowers CoQ10 and vitamin E

- Inositol supplements benefit metabolic syndrome

- Omega 3 status affects asthma symptoms






CLINICAL UPDATE - Low magnesium associated with sudden cardiac death

In the Atherosclerosis Risk in Communities (ARIC) Study, over 14,000 people between the ages of 45 and 64 were tested for magnesium levels and followed for an average of 12 years. A reduction of almost 40% in sudden cardiac death was observed in people with the highest levels of magnesium.  In a similar but smaller study, magnesium supplementation was shown to improve endothelial function in diabetics.

(American Heart Journal, September 2010)

(Magnesium Research, August 2010)

LINK to ABSTRACT Serum magnesium and risk of sudden cardiac death in the Atherosclerosis Risk in Communities (ARIC) Study.

LINK to ABSTRACT Oral magnesium supplementation improves vascular function in elderly diabetic patients.


CLINICAL UPDATE - mechanism behind choline's effect on behavior explored

Investigation into the effects of choline deprivation show how choline-deprived rats experience less mitochondrial respiration in their brains and more oxidative stress than those fed a normal choline-containing diet. In the choline-deficient diet, the powerful antioxidant glutathione was used up more quickly, indicating a synergistic effect of choline and glutathione.  The clinical result of choline deprivation was learning and motor function impairment.

(Journal Nutrition, June 2010)
LINK to ABSTRACT Dietary choline deprivation impairs rat brain mitochondrial function and behavioral phenotype.





CLINICAL UPDATE - Is intravenous use of vitamin C safe?

An analysis of more than 20,000 patients that were given intravenous vitamin C for clinical reasons such as infection, cancer and fatigue showed intravenous vitamin C is more widely used than expected by authors of the study and its use is regarded as generally very safe.

(PLoS One, July 2010)
LINK to ABSTRACT Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects.






CLINICAL UPDATE - hormone contraception lowers coq10 and vitamin E

When three hormonal contraception methods of delivery were evaluated – transdermal, oral and vaginal – and compared against a group of women not taking any hormonal contraception, researchers discovered that the levels of coenzyme Q10, vitamin e and total antioxidant capacity were significantly lower in the women using hormonal contraception, regardless of the method of delivery.

(Obstetrics and Gynecology International, August 2010)
LINK to ABSTRACT Effects of oral, vaginal, and transdermal hormonal contraception on serum levels of coenzyme q(10), vitamin e, and total antioxidant activity.






CLINICAL UPDATE - inositol supplements benefit metabolic syndrome

Inositol, which has demonstrated insulin-sensitizing effects in past studies, was given to eighty post-menopausal women that had metabolic syndrome.  After 6 months of 2 grams daily inositol supplementation, the women were evaluated for insulin resistance, lipids and blood pressure.  Compared to a similar group given placebo, the inositol-supplemented group showed improvement in blood pressure (down 11%), triglyceride levels (down 20%) and HDL levels (up 22%).

(Menopause, September 2010)
LINK to ABSTRACT Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study.





CLINICAL UPDATE - omega 3 status affects asthma symptoms

A group of 38 asthmatic people who were allergic to grass pollen were compared to a non-asthmatic control group.  The asthmatic group has significantly higher ratios of omega 6  to omega 3 fatty acids, with a clinical result of higher bronchial inflammation.

(Respiratory Medicine, July 2010)
LINK to ABSTRACT Omega-3 polyunsaturated fatty acids and bronchial inflammation in grass pollen allergy after allergen challenge.