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September 2010 - Volume 4, Issue 09


In this issue...

- Why fish oils work swimmingly against diabetes

- Low B vitamin status raises cancer risk

- Evidence mounts for gene-nutrient theory of disease

- Levels of CoQ10 in mom affects infant birth weight

- More reasons why omega 3 fatty acids are critical in pregnancy

- Study supports prostate cancer benefits of tocotrienols

- Vitamin C improves mood






CLINICAL UPDATE - Why fish oils work swimmingly against diabetes

Researchers at the University of California, San Diego School of Medicine have identified the molecular mechanism that makes omega-3 fatty acids so effective in reducing chronic inflammation and insulin resistance.

(Cell, September 2010)


LINK to ABSTRACT GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects


LINK to ABSTRACT The omega-3 fatty acids EPA and DHA decrease plasma F(2)-isoprostanes: Results from two placebo-controlled interventions.


CLINICAL UPDATE - Low b vitamin status raises cancer risk

An eight year study which measured the level of four B vitamins – B2 (riboflavin), B6 (pyridoxine), B9 (folate) and B12 (cobalamin) – on more than 500,000 people showed that lower levels of B vitamins increased the risk of lung cancer, in both smokers and non-smokers.

(Journal of the American Medical Association, June 2010)
LINK to ABSTRACT Serum B vitamin levels and risk of lung cancer.





CLINICAL UPDATE - Evidence mounts for the gene-nutrient theory of disease

Mounting research supports the idea that micronutrients affect gene expression and conversely that individual genes affect the levels of micronutrients needed by individuals. Investigation into specific genes for vitamins C, D and E strongly support the notion that biochemical individuality profoundly impacts micronutrient status.

(American Journal of Clinical Nutrition; May, June, July 2010)

(Lancet, July 2010)
LINK to ABSTRACT Dietary reference values of individual micronutrients and nutriomes for genome damage prevention: current status and a road map to the future.

LINK to ABSTRACT Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants.

LINK to ABSTRACT IL-2 and IL-10 gene polymorphisms are associated with respiratory tract infection and may modulate the effect of vitamin E on lower respiratory tract infections in elderly nursing home residents.

LINK to ABSTRACT Common genetic determinants of vitamin D insufficiency: a genome-wide association study.






CLINICAL UPDATE - levels of coq10 in mom affects infant birth weight

Levels of the lipid-soluble antioxidant coQ10 were measured in 50 healthy pregnant women at each trimester.  Results showed that levels of maternal coQ10 is positively associated with fetal growth, especially in the third trimester.

(Biofactors, July 2010)
LINK to ABSTRACT Positive correlation between maternal serum coenzyme Q10 levels and infant birth weight.





CLINICAL UPDATE - more reasons why omega 3 fatty acids are critical in pregnancy

Five year old children whose mothers received DHA versus placebo while breastfeeding scored higher on a test of sustained attention.  In a recent animal study, researchers found that healthy omega 3 fatty acid status during pregnancy protected offspring from neonatal brain injuries.

(Pediatrics, July 2010)

(Stroke, August 2010)
LINK to ABSTRACT Effects of Early Maternal Docosahexaenoic Acid Intake on Neuropsychological Status and Visual Acuity at Five Years of Age of Breast-Fed Term Infants.

LINK to ABSTRACT Omega-3 Polyunsaturated Fatty Acid Supplementation Confers Long-Term Neuroprotection Against Neonatal Hypoxic-Ischemic Brain Injury Through Anti-Inflammatory Actions.






CLINICAL UPDATE - study supports prostate cancer benefits of tocotrienols

The link between Vitamin E and cancer benefits has received extra backing from a new study, which found that a mix of different forms of the vitamin helped prevent prostate tumor growth in mice.

(Nutrition and Cancer, August 2010)

LINK to ABSTRACT Mixed tocotrienols inhibit prostate carcinogenesis in TRAMP mice.






CLINICAL UPDATE - vitamin C improves mood

In a double-blind clinical trial, mood was assessed with a standardized test on hospitalized patients that were given 500mg of vitamin C and 1000 IU of vitamin D twice daily.  Vitamin C levels were associated with a 34% reduction in mood disturbance  while no effect was seen for vitamin D levels.

(Nutrition, August 2010)
LINK to ABSTRACT Vitamin C provision improves mood in acutely hospitalized patients.