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May 2010 - Volume 4, Issue 05


In this issue...

- Vitamin E superior to drug therapy for fatty liver

- Omega 3 DHA may boost male fertility

- CoQ10 regulates immune function

- Vitamin A role in energy metabolism elucidated

- Lipoic acid benefits blood vessels, Alzheimer’s and PCOS

- Low vitamin B6 may increase Parkinson’s disease risk

- Omega-3 may slash risk of heart failure







CLINICAL UPDATE - Vitamin E superior to drug therapy for fatty liver

In a randomized controlled trial on 247 adults with nonalcoholic steatohepatitis (fatty liver), daily supplementation with 800IU of vitamin E was compared to therapy with the prescription drug pioglitazone and placebo.  After 96 weeks, the vitamin E group showed improved liver histology markers and experienced less weight gain than either the drug or placebo group.

(New England Journal of Medicine, May 2010)

LINK to ABSTRACT  Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis.





CLINICAL UPDATE - omega 3 dha may boost male fertility

Supplements of the omega-3 fatty acid DHA (docosahexaenoic acid) may reverse abnormalities in sperm associated with infertility, suggests a new study with mice. Similarly, a recent review concluded that antioxidant therapy could also improve sperm quality and pregnancy rates.

(Journal of Lipid Research, February 2010)

(Clinical Nutrition, February 2010)
(Reproductive Biomedicine Online, March 2010)

LINK to ABSTRACT Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice.

LINK to ABSTRACT Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men.

LINK to ABSTRACT A systematic review of the effect of oral antioxidants on male infertility.





CLINICAL UPDATE - CoQ1o regulates immune function

After human blood mononuclear cells were incubated for 24 hours with four different levels of coenzyme Q10, there was a significant decrease in the TNF (tumor necrosis factor) inflammatory cytokines, suggesting that CoQ10 exerts a specific regulatory role on immune function.

(Journal of Nutritional Science and Vitaminology, 2010)

LINK to ABSTRACT Coenzyme Q10 decreases TNF-alpha and IL-2 secretion by human peripheral blood mononuclear cells.






CLINICAL UPDATE - vitamin A role in energy metabolism elucidated

The role of retinol in mitochondrial energy metabolism was investigated by a group of scientists at Cornell Medical School.   They found that intracellular levels of the retinol form of vitamin A affected cellular respiration and energy output, which explains why vitamin A deficiency affects so many diseases, they concluded.

(Journal of the Federation of American Societies for Experimental Biology, February 2010)
LINK to ABSTRACT Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis.





CLINICAL UPDATE - lipoic acid benefits blood vessels, alzheimers and pcos

The benefits of lipoic acid are multi-faceted, according to new research.  In patients with subclinical hypothyroidism, alpha lipoic acid improved endothelial function.  In another study on mice, lipoic acid protected against neural injury commonly seen in Alzheimers patients.  In yet another study, controlled-release alpha lipoic acid improved insulin sensitivity, lowered triglycerides and favorable changed LDL subclass distribution in patients with PCOS (polycystic ovary syndrome.)

            (Experimental and Clinical Endocrinology and Diabetes, February 2010)

(International Journal of Molecular Medicine, March 2010)
(Journal of Diabetes Science and Technology, March 2010)
LINK to ABSTRACT Alpha-lipoic Acid Improves Endothelial Dysfunction in Patients with Subclinical Hypothyroidism.

LINK to ABSTRACT The combination of exercise training and alpha-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice.

LINK to ABSTRACT Effects of Controlled-Release Alpha Lipoic Acid In Lean, Nondiabetic Patients with Polycystic Ovary Syndrome.





CLINICAL UPDATE - low vitamin B6 may increase parkinson's disease risk

Insufficient levels of vitamin B6 may increase the risk of Parkinson’s disease by about 50%, says a new study from Japan

             (British Journal of Nutrition, March 2010)

(Neurology, 2006)


LINK to ABSTRACT Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case-control study in Japan.

LINK to ABSTRACT Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease.






CLINICAL UPDATE - omega 3 may slash risk of heart failure

Increased intakes of fatty fish, and the omega-3s they contain, may reduce a woman’s risk of heart failure by about 25%, according to new findings from the US and Sweden

             (European Journal of Clinical Nutrition, March 2010)

(European Heart Journal, June 2009)

LINK to ABSTRACT Fatty fish, marine omega-3 fatty acids and incidence of heart failure.

LINK to ABSTRACT Fish consumption, marine omega-3 fatty acids, and incidence of heart failure: a population-based prospective study of middle-aged and elderly men.