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November 2009 - Volume 3, Issue 11

 

In this issue...

- Antioxidants may combat influenza virus

- Carnitine therapy increases LDL particle size

- Telomere length affects fertility

- Nearly half of people with liver or pancreatic disease have vitamin D and K deficiency

- Carnitine inhibits cancer cell proliferation in the colon

- Zinc protects more than the prostate

 

 

                                                                                                                                                

 

 

 

CLINICAL UPDATE - antioxidants may combat the influenza virus

Researchers found that proteins from the influenza virus cause damage by increasing reactive oxygen species in epithelial cells and that the powerful antioxidant glutathione helps prevent this damage.

(Federation of American Societies for Experimental Biology, November 2009)
LINK to ABSTRACT Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species

 

 

 

 

CLINICAL UPDATE - carnitine therapy increases ldl particle size

80 diabetic patients were given statin monotherapy or statin plus carnitine.  After three months, the group that took simvastatin plus carnitine showed a reduction in the dangerous small-dense LDL, an increase in LDL particle size and an increase in HDL, changing their overall lipid profile to a less atherogenic one.

(Metabolism, November 2009)
LINK to ABSTRACT Effect of L-carnitine on the size of low-density lipoprotein particles in type 2 diabetes mellitus patients treated with simvastatin.

 

 

 

 

CLINICAL UPDATE - Telomere length affects fertility

After measuring the telomeres of 54 young women (<37 years old) who were undergoing in vitro fertilization, researchers found telomeres to be shorter in women with ovarian insufficiency versus those whose infertility was due to their male partners or an anatomical problem.

(The Journal of Clinical Endocrinology and Metabolism, October 2009)

(Reproduction, Fertility and Development, 2009)
LINK to ABSTRACT Correlation of Telomere Length and Telomerase Activity with Occult Ovarian Insufficiency.

LINK to ABSTRACT Telomeres and reproductive aging.

 

 

 

 

CLINICAL UPDATE - nearly half of people with liver or pancreatic disease have vitamin D and K deficiency

Researchers sought to evaluate the prevalence of deficiency in the fat soluble vitamins D and K, specifically in patients with fat malabsorption issues, concluding that that liver dysfunction is actually predictive of vitamin K deficiency and decreased production of osteocalcin. 

(Nutrition Research, September 2009)
LINK to ABSTRACT Prevalence of vitamin K and D deficiency in patients with hepatobiliary and pancreatic disorder

 

 

 

 

 

CLINICAL UPDATE - Carnitine inhibits cancer cell proliferation in the colon

When carnitine was administered to colon cancer cells, it enhanced the bioavailability of the short-chain fatty acid butyrate, ultimately inhibiting cancer cell proliferation and inducing cell death in cancerous colon cells.

(Nutrition, November 2009)
LINK to ABSTRACT In vitro studies on the inhibition of colon cancer by butyrate and carnitine.

 

 

 

 

CLINICAL UPDATE - ZInc protects more than the prostate

Data strongly suggest that zinc plays a protective role against prostate cancer through various mechanisms such as repairing DNA and suppressing tumors.  Similarly, since it functions as a signal molecule for immune cells, zinc supplementation demonstrates therapeutic benefit for several infectious diseases and has even prevented certain types of blindness in the elderly, according to a recent review.

(Current Opinion in Clinical Nutrition and Metabolic Care, November 2009)
(Current Opinion in Clinical Nutrition and Metabolic Care, November 2009)
LINK to ABSTRACT Zinc and prostate cancer.

LINK to ABSTRACT Zinc: role in immunity, oxidative stress and chronic inflammation.