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October 2009 - Volume 3, Issue 10


In this issue...

- Carnitine therapy reduces hypertension

- Vitamin D deficiency increases risk of anemia

- Glutathione depletion common in celiac patients

- Homocysteine hurts telomeres while HDL helps them

- Low antioxidant status increases the risk of pre-eclampsia







CLINICAL UPDATE - Carnitine therapy reduces hypertension

32 non-diabetic patients with increased cardiovascular risk were given oral acetyl-L-carnitine twice daily for 24 weeks. The carnitine therapy safely reduced hypertension, insulin resistance and glucose tolerance.

(Hypertension, September 2009)

LINK to ABSTRACT:  Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapy.





CLINICAL UPDATE - Vitamin D deficiency increases risk of anemia

Vitamin D and hemoglobin levels were measured on 554 people.  An association was found between vitamin D deficiency and risk of anemia, supporting the hypothesis that vitamin D plays a role in the production of red blood cells.

(Annals of Hematology, September 2009)

LINK to ABSTRACT: Vitamin D deficiency and anemia: a cross-sectional study.





CLINICAL UPDATE - glutathione depletion common in celiac patients

Intestinal biopsies of 39 pediatric celiac patients were compared to 19 control patients and researchers found that glutathione-based antioxidant capacity was significantly reduced in the celiac patients.

(Clinical Biochemistry, September 2009)

LINK to ABSTRACT: Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease.





LINICAL UPDATE - Homocysteine hurts telomeres while hdl helps them

A study on the telomeres of 90 adults demonstrated a significant inverse correlation between telomere length and homocysteine in men.  Similarly, in a study on over 650 adults, slower telomere shortening was observed in those with high levels of HDL cholesterol.

(Rejuvenation Research, September 2009)

(Atherosclerosis, August 2009)

LINK to ABSTRACT: Telomere Length in Lymphocytes of Older South Australian Men May Be Inversely Associated with Plasma Homocysteine.

LINK to ABSTRACT: Leukocyte telomere length is associated with HDL cholesterol levels: The Bogalusa heart study.





CLINICAL UPDATE - low antioxidant status increases risk of pre-eclampsia

A review of studies from 1986-2007 concluded that patients with documented cases of pre-eclampsia typically have lower levels of vitamins E and C as well as higher lipid peroxidation markers.

(Obstetrical & Gynecological Survey, September 2009)

LINK to ABSTRACT: Lipid peroxidation and antioxidant status in preeclampsia: a systematic review.