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September 2009 - Volume 3, Issue 09


In this issue...

- Vitamin K deficiency may accelerate diseases of aging

- ApoB and non-HDL cholesterol not clinical equivalents

- Correcting deficiencies in vitamins B, C and D improves endothelial function

- Low choline status associated with high anxiety

- Vitamin B12 deficiency common in diabetics

- Antioxidant supplementation reduced healing time in pediatric burns






CLINICAL UPDATE - Vitamin K deficiency may accelerate diseases of aging

Current recommendations for vitamin K are not being met, placing people at increased risk of age-related diseases such as cancer and heart disease, says a new analysis

(American Journal of Clinical Nutrition, October 2009)
(Proceedings of the National Academy of Sciences of USA, 2006)


LINK to ABSTRACT: Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?

LINK to ABSTRACT: Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage.






CLINICAL UPDATE - ApoB and non-hdl cholesterol not clinical equivalents

Although there is a high correlation between apoB and non-HDL cholesterol, this paper presents a series of examples where apoB and non-HDL cholesterol differ dramatically, thus altering the clinical diagnosis significantly.

(Current Atherosclerosis Reports, September 2009)

LINK to ABSTRACT: ApoB versus non-HDL-C: what to do when they disagree.





CLINICAL UPDATE - correcting deficiencies in vitamins b, c and D improves endothelial function

Researchers found that dilation of blood vessels improved dramatically in 23 asymptomatic but vitamin D deficient people who were supplemented with vitamin D for 3 months.  A randomized clinical trial of B vitamins and garlic extract on 65 intermediate risk patients supplemented for one year significantly reduced the progression of atherosclerosis.  Similarly, a recent review on vitamin C discusses how it can help induce vasodilation.

(Journal of Clinical Endocrinology and Metabolism,  July 2009)

(Preventive Medicine, June 2009)

(Basic and Clinical Pharmacology and Toxicology, June 2009)
LINK to ABSTRACT Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects.

LINK to ABSTRACT Aged Garlic Extract Supplemented with B Vitamins, Folic Acid and L-Arginine Retards the Progression of Subclinical Atherosclerosis: A Randomized Clinical Trial.

LINK to ABSTRACT Role of marginal vitamin C deficiency in atherogenesis: in vivo models and clinical studies.





CLINICAL UPDATE - low choline status associated with high anxiety

Over 5900 patients were studied and researchers found that low choline levels were significantly associated with anxiety symptoms.

(American Journal of Clinical Nutrition, August 2009)
LINK to ABSTRACT Choline in anxiety and depression: the Hordaland Health Study.





cLINICAL UPDATE - vitamin B12 deficiency common in diabetics

In a study of 203 type II diabetics, researchers confirmed a B12 deficiency in 22% of patients, and those taking metformin had even lower levels of B12.  In a similar study in India, vitamin B12 deficiency during pregnancy was associated with obesity, insulin resistance and gestational diabetes.

(Journal of the American Board of Family Medicine, September 2009)
(Diabetologia, August 2009)
LINK to ABSTRACT The prevalence of vitamin B(12) deficiency in patients with type 2 diabetes: a cross-sectional study.


LINK to ABSTRACT  Low plasma vitamin B(12) in pregnancy is associated with gestational 'diabesity' and later diabetes





CLINICAL UPDATE - antioxidant supplementation reduced healing time in pediatric burns

A randomized controlled trial of 32 children with burn injuries showed that supplementation with vitamin C, E and zinc reduced their wound healing time and markers of oxidative stress while in the hospital.

(Journal of Burn Care and Research, August 2009)
LINK to ABSTRACT  Supplementation of Vitamin E, Vitamin C, and Zinc Attenuates Oxidative Stress in Burned Children: A Randomized, Double-Blind, Placebo-Controlled Pilot Study