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July 2009 - Volume 3, Issue 07

 

In this issue...

- Folate status as important as iron in anemia

- Lowering homocysteine with B vitamins helped migraine sufferers

- Telomere length predicts severity of diabetic complications

- Choline supplementation lowers oxidative stress from asthma

- Amino acid dramatically improves Post Traumatic Stress Disorder

 

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CLINICAL UPDATE - Folate status as important as iron in anemia

Iron deficiency only explained about 10% of anemia cases when 2812 children were examined for hemoglobin, ferritin and intracellular folate levels.  Researchers found that hemoglobin concentrations were strongly and inversely associated with folate levels, especially when the person has low vitamin B12 status.

(European Journal of Clinical Nutrition, July 2009)

Link to ABSTRACT: Hemoglobin concentration is inversely associated with erythrocyte folate concentrations in Colombian school-age children, especially among children with low vitamin B12 status.

 

 

 

 

CLINICAL UPDATE - Lowering homocysteine with b vitamins helped migraine sufferers

A randomized double-blind trial of 52 migraine patients showed that supplementation with vitamin B6 and B12 for six months lowered homocysteine levels by 39% while dramatically reducing the pain and frequency of their migraine attacks.

(Pharmacogenetics and Genomics, June 2009)

Link to ABSTRACT: The effects of vitamin supplementation and MTHFR(C677T) genotype on homocysteine-lowering and migraine disability.

 

 

 

 

CLINICAL UPDATE - TELOMERE LENGth predicts severity of diabetic complications

A recent study from Finland evaluated the telomere length of 132 type I diabetics and found that shorter telomeres predicted the severity and progression of diabetic nephropathy in these patients.

(Journal of Internal Medicine, June 2009)

Link to ABSTRACT: Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes.

 

 

 

 

CLINICAL UPDATE - choline supplementation lowers oxidative stress from asthma

Researchers evaluated mice with induced asthma and found that choline administration taken with alpha-lipoic acid significantly reduced oxidative stress, lowered production of reactive oxygen species, and suppressed common inflammatory markers associated with asthma.

(European Journal of Clinical Investigation, June 2009)

Link to ABSTRACT: Choline supplementation reduces oxidative stress in mouse model of allergic airway disaese.

 

 

 

 

CLINICAL UPDATE - AMino ACid dramatically improves post traumatic stress disorder

Twenty-two patients underwent a randomized, controlled, double-blind trial to determine whether the administration of the amino acid serine would alleviate Combat-Related PTSD.  Results showed that supplementation with serine for 6 weeks significantly reduced anxiety and dramatically improved clinical assessment of PTSD.

(International Journal of Neuropsychopharmacology, April 2009)

Link to ABSTRACT:  Pilot controlled trial of d-serine for the treatment of post-traumatic stress disorder.