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February 2009 - Volume 3, Issue 02


In this issue...

- Vitamin B12 deficiency not detected in serum

- Can vitamin D cure back pain?

- High remnant lipoprotein levels predict stroke

- Vitamin E protects against exercise-induced free radicals

- Is CoQ10 the ultimate multi-tasker?

- LDL size is excellent marker of atherosclerosis





CLINICAL UPDATE - vitamin B12 deficiency not detected in serum

Recent case is described where improper absorption of vitamin B12 led to a functional B12 deficiency that was undetected by conventional serum testing, ultimately delaying diagnosis and possibly causing subsequent neurological damage

(Practical Neurology, February 2009)

Link to ABSTRACT: Functional vitamin B12 deficiency.





CLINICAL UPDATE - Can vitamin d cure back pain?

Six cases are described where repletion of vitamin D resolved back pain or significantly improved patients' quality of life, even after failed back surgery.

(Journal of the American Board of Family Medicine, February 2009)

Link to ABSTRACT:  Improvement of chronic back pain or failed back surgery with vitamin D repletion: a case series.





CLINICAL UPDATE - High remnant lipoprotein levels predict stroke

Study followed 292 metabolic syndrome patients for two years that had mild carotid plaque and found that high levels of the atherogenic triglyceride-rich lipoprotein RLP is an independent risk factor for ischemic stroke.

(Atherosclerosis, January 2009)

Link to ABSTRACT: High serum levels of remnant lipoproteins predict ischemic stroke in patients iwth metabolic syndrome and mild carotid atherosclerosis.




CLINICAL UPDATE - vitamin e protects against exercise-induced free radicals

A group of healthy basketball players that were supplemented for one month with vitamin E pre- and post-exercise showed that alpha-tocopherol protected enzyme activity in the athletes from free radical production

(European Journal of Clinical Nutrition, February 2009)

Link to ABSTRACT: Alpha-tocopherol supplementation prevents the exercise-induced reduction of serum paraoxonase 1/arylesterase activities in healthy individuals.




CLINICAL UPDATE - is coq10 the ultimate multitasker?

Coenzyme Q10 supplementation reduces risk of pre-eclampsia during pregnancy, helps fibromyalgia patients, could improve recovery from cardiac surgery, and may even minimize tumors in breast cancer.

(International Journal of Gynecology and Obstetrics, January 2009)

(Clinical Biochemistry, December 2008)

(Journal of Cardiothoracic and Vascular Anesthesia, December 2008)

(The British Journal of Nutrition, December 2008)

Link to ABSTRACT: Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia.

Link to ABSTRACT:  Coenzyme Q10 distribution in blood is altered in patients with fibromyalgia.

Link to ABSTRACT:  The role of oral coenzyme Q10 in patients undergoing coronary artery bypass graft surgery.

Link to ABSTRACT: Coenzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy.




CLINICAL UPDATE - LDL size is excellent marker of atherosclerosis

Recent study of over 3000 people showed that small, dense LDL was a better marker of carotid atherosclerosis than apo B, non-HDL cholesterol, or even plasma triglycerides.

(Atherosclerosis, February 2009)

Link to ABSTRACT: Small dense low-density lipoprotein cholesterol concentration and carotid atherosclerosis.