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July 2008 - Volume 2, Issue 07


In this issue...

- Vitamin C benefits heart health by several mechanisms

- Epidemiological evidence mounts for Lp-PLA2 as heart disease marker

- B12 deficiency may be passed to infants by mom

- Vitamin D status during pregnancy affects infant's teeth

- Lp(a) values are lower in women on hormone therapy

- Antioxidants protect against cataract


SpectraCell News...

- Spectracell adds vitamin C to its MicroNutrient Test Read more...

- Spectracell adds Lp-PLA2 to its LPP+ test  Read more....






CLINICAL UPDATE - vitamin C benefits heart health by several mechanisms

The antioxidant regulates endothelial function and reduces the progression of carotid atherosclerosis

(Journal of Physiology, May 2008)

(Nutrition, Metabolism and Cardiovascular Disease, May 2008)

Link to ABSTRACT: Acute and chronic effects  of vitamin C on endothelial fibrinolytic capacity in overweight and obese adult humans. 

Link to ABSTRACT: Vitamin C consumption is associated with less progression in carotid intima media thickness in elderly men: A 3-year intervention study.




CLINICAL UPDATE - epidemiological evidence mounts for lp-pla2 as heart disease marker

Two large clinical trials - Veteran Affairs HDL Intervention Trial and the Cardiovascular Health Study - implicate lipoprotein-associated phospholipase A2 (Lp-PLA2) as strong marker of cardiovascular disease.

(Arteriosclerosis, Thrombosis and Vascular Biology, June 2008)

(Journal of the American Geriatric Society, May 2008)

Link to ABSTRACT: Cardiovascular events with increased lipoprotein-associated phospholipase A2 and low high-density lipoprotein cholesterol: the Veteran Affairs HDL Intervention Trial.

Link to ABSTRACT: Distribution and correlates of lipoprotein-associated phospholipase A2 in an elderly cohort: the Cardiovascular Health Study.




clINICAL UPDATE - B12 deficiency may be passed to infants by mom

Evidence suggests that vitamin B12 deficiency, which can cause severe neurological damage in infants, may stem from maternal deficiencies, especially in cases of pernicious anemia

(Nutrition Reviews, May 2008)

Link to ABSTRACT: Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms.




clINICAL UPDATE - vitamin d status during pregnancy affects infants' teeth

Higher intakes of vitamin D during pregnancy may lead to stronger teeth in children

(International Association for Dental Research, July 2008)

(Lancet, January 2006)

(Canadian Medical Association Journal, April 2006)


Link to ABSTRACT: Influence of maternal vitamin status on infant oral health

Link to ABSTRACT: Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study.

Link to ABSTRACT:  Association of low intake of milk and vitamin D during pregancy with decreased birth weight.





clINICAL UPDATE - hormone therapy changes Lp(a)

Women on hormone therapy have lower Lp(a) values causing a weaker link between Lp(a) and future cardiovascular events

(Journal of the American College of Cardiology, July 2008)

Link to ABSTRACT: Lipoprotein(a), Hormone Replacement Therapy, and Risk of Future Cardiovascular Events




clINICAL UPDATE - Antioxidants protect against cataract

Higher intakes of vitamin C and other antioxidants reduced incidence of age-related cataract in a group studies for 10 years

(American Journal of Clinical Nutrition, June 2008)

Link to ABSTRACT: Antioxidant nutrient intake and the long-term incidence of age-related cataract: the Blue Mountain Eye Study.