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MTHFR Polymorphism Library

(5,10-methylenetetrahydroreductase polymorphism)

See also GENE EXPRESSIONHOMOCYSTEINE, FOLATE,  VITAMIN B6 and VITAMIN B12

Click here for Clinical Update (1)

2011 Am J Clin Nutr

MTHFR 677C->T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation. 

2011 Eur J Clin Nutr

Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype.

2011 J Nutr

Methylenetetrahydrofolate Reductase Variants That Associate with Hypertension and Cardiovascular Disease Interact with Dietary Polyunsaturated Fatty Acids to Modulate Plasma Homocysteine in Puerto Rican Adults. 

2011 J Nutr

Nutritional genomics: defining the dietary requirement and effects of choline.

2011 J Nutr

Polymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans.

2010 Braz J Med Biol Res

Genetics of homocysteine metabolism and associated disorders.

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2010 Clin Drug Investig

Associations between the C677T and A1298C polymorphisms of MTHFR and the efficacy and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis.

2010 Headache

MTHFR 677C>T and ACE D/I polymorphisms in migraine: a systematic review and meta-analysis.

2010 J Epidemiol

Genetic polymorphisms in homocysteine metabolism and response to folate intake: a comprehensive strategy to elucidate useful genetic information.

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2010 J Sex Med

Treatment of erectile dysfunction due to C677T mutation of the MTHFR gene with vitamin B6 and folic acid in patients non responders to PDE5i.

2010 Proc Nutr Soc

Postgraduate Symposium: The MTHFR C677T polymorphism, B-vitamins and blood pressure.

2009 J Nutr

Telomere Length in Peripheral Blood Mononuclear Cells Is Associated with Folate Status in Men.

2009 J Rheumatol

Metaanalysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity.

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2009 Pharmacogenet Genomics

The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability.

2009 Rinsho Byori

Bone quality markers: pentosidine, homocysteine, and MTHFR polymorphism

2008 Alt Med Rev

The methylation, neurotransmitter, and antioxidant connections between folate and depression. 

2008 J Cell Mol Med

One carbon metabolism disturbances and the C667T MTHFR gene polymorphism in children with autism spectrum disorders. 

2008 J Nutr Biochem

Folate intake and the MTHFR C677T genotype influence choline status in young Mexican American women

2008 J Pediatr

Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors. 

2007 Headache

Efficacy of folic acid in children with migraine, hyperhomocysteinemia and MTHFR polymorphisms 

2007 J Mol Diagn

Improved real-time multiplex polymerase chain reaction detection of methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C polymorphisms using nearest neighbor model-based probe design.

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2006 Cancer Res

Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c.

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2005 Circulation

Cardiology patient pages. Homocysteine and MTHFR mutations: relation to thrombosis and coronary artery disease.

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2005 Clin Gastroenterol Hepatol

Prevalence of hyperhomocysteinemia in adult gluten-sensitive enteropathy at diagnosis: role of B12, folate, and genetics.

2005 J Assist Reprod Genet

MTHFR C677T polymorphism associates with unexplained infertile male factors. 

2004 J Clin Oncol

DNA methylation and cancer.

2003 Arch Gen Psychiatry

Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study

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2002 J Nutr

Gene-nutrient interactions and DNA methylation

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2002 Pharmacogenetics

Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses. 

1999 Proc Natl Acad Sci USA

Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults.

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1997 Cancer Res

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.

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1996 Am J Hum Genet

Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

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