Below is a list of nutrients which significantly affect Hypothyroidism:

• Glutathione - Hypothyroidism decreases efficacy of some antioxidants, such as glutathione peroxidase and superoxide dismutase
• B Vitamins - A deficiency in B6, B12 or B9 (folate) can cause elevated homocysteine, which is linked with hypothyroidism. Folic acid levels have been linked to levels of thyroid stimulating hormone (TSH).
• Vitamin C and E - Partially restores thyroid function when liver detoxification ability is compromised.
• Vitamin A - Activates gene that regulates TSH (thyroid stimulating hormone)
• Zinc - Increases thyroid hormone T3 in deficient subjects.
• Copper - Low levels seen in experimentally induced hypothyroidism; Indirectly affects thyroid status by its antioxidant role via superoxide dismutase.
• Selenium - Converts thyroid hormone T4 (thyroxine) into T3 (triiodothyronine); Deficiency reduces T3 levels causing classic hypothyroidism symptoms such as fatigue, depression or weight gain.
• Asparagine - This amino acid is part of the structure of thyroid stimulating hormone which regulates communication with other hormones.
• Carnitine - Decreased tissue levels of carnitine in both hypo- and hyperthyroidism contribute to muscle fatigue.
• Lipoic Acid - Improves endothelial function in people with subclinical hypothyroidism; Protects thyroid cells from oxidative stress; May interfere with T4 therapy
• Choline - Hypothyroidism negatively affects choline function in the brain, which can affect mood and cognition.