April 2012 - Volume 6, Issue 4
In this issue..
- Selenium: Know if you have too much of a good thing
- Nutrient deficiency causing heavy metal toxicity?
- Meta-analysis finds vitamin C supplements lower blood pressure
- Folic acid lowers oxidative stress in hypothyroidism
- CoQ10 protects liver from acetaminophen toxicity
- Vitamin E may help infertile women
- Biotin deficiency impairs carbohydrate metabolism
CLINICAL UPDATE - SELENIUM: KNOW IF YOU HAVE TOO MUCH OF A GOOD THING
An exhaustive review of the benefits selenium has on human health emphasizes that there is a definite “U-shaped link with status.” The paper epitomizes the philosophy that more-is-not-always-better for vitamins and minerals. Although low selenium status has been linked to several diseases – heart disease, infertility, low immunity, poor cognitive function, thyroid disease and cancer – the authors state that although “additional selenium intake may benefit individuals with low status, those with adequate status might be affected adversely and should not take selenium supplements.”
(Lancet, March 2012)
LINK to ABSTRACT Selenium and human health.
CLINICAL UPDATE - NUTRIENT DEFICIENCY CAUSING HEAVY METAL TOXICITY?
A case study on a 37 year old man suggests that multiple micronutrient deficiencies played a role in the cause of his multiple sclerosis. The authors state he had several key nutrient deficiencies, which they think impaired his ability to excrete harmful metals. They sate that “nutritional treatment may be an effective approach to this disease” due to the role of nutrients in various detoxification pathways.
(Current Aging Science, Epub ahead of print in August 2011)
LINK to ABSTRACT Influence of Essential Trace Minerals and Micronutrient Insufficiencies on Harmful Metal Overload in a Mongolian Patient with Multiple Sclerosis.
CLINICAL UPDATE - META-ANALYSIS FINDS VITAMIN c SUPPLEMENTS LOWER BLOOD PRESSURE
In a review of 29 randomized controlled trials of oral vitamin C, authors found that vitamin C supplements reduced both systolic and diastolic blood pressure. The reduction in blood pressure was more pronounced in people with existing hypertension. In another meta-analysis, magnesium supplementation also lowered blood pressure.
(American Journal of Clinical Nutrition, May 2012)
(European Journal of Clinical Nutrition, April 2012)
LINK to ABSTRACT Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials.
LINK to ABSTRACT Effect of magnesium supplementation on blood pressure: a meta-analysis.
CLINICAL UPDATE - FOLIC ACID LOWERS OXIDATIVE STRESS IN HYPOTHYROIDISM
In two separate studies, antioxidant function was evaluated after hypothyroidism was induced. Since basal metabolic rate is lower in hypothyroism and most oxidative stress in the body stems from basic metabolic functions, some researchers hypothesize that hypothyroidism should result in lower levels of oxidative stress. But in this recent animal study, the authors found higher levels of oxidative stress in the hypothyroid (vs normal thyroid) state, as well as higher levels of homocysteine. Treatment with folic acid ameliorated these effects. In another study, authors found that hypothyroidism reduced antioxidant function, although the serum levels of several antioxidants (vitamins A, C & E) remained constant.
(Toxicology and Industrial Health, April 2012)
(Endokrynologia Polska, 2011)
LINK to ABSTRACT The effect of folic acid as an antioxidant on the hypothalamic monoamines in experimentally induced hypothyroid rat.
LINK to ABSTRACT Elements of oxidation/reduction balance in experimental hypothyroidism.
CLINICAL UPDATE - COQ10 PROTECTS LIVER FROM ACETAMINOPHEN TOXICITY
A single toxic dose of acetaminophen was administered in an animal study and liver damage was monitored. After 1 hour and after 12 hours, an injection of coenzyme Q10 was given. The results showed that the coQ10 injections protected the liver from acetaminophen-induced damage. The coQ10 also attenuated the loss of zinc and selenium that occurred after acetaminophen administration.
(Environmental Toxicology and Pharmacology, March 2012)
LINK to ABSTRACT Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity.
CLINICAL UPDATE - VITAMIN E MAY HELP INFERTILE WOMEN
103 women with unexplained infertility were divided into two groups – 50 women were given a drug to induce ovulation (clomiphene citrate) combined with 400IU per day of vitamin E and 53 women were induced to ovulate without the administration of vitamin E. The supplemented group had a significantly thicker endometrium and authors suggest that vitamin E may be beneficial to women with unexplained infertility by improving the “endometrial response” and that it may “modulate the antiestrogenic effect of clomiphene citrate.”
(Journal of Assisted Reproduction and Genetics, February 2012)
LINK to ABSTRACT Vitamin E effect on controlled ovarian stimulation of unexplained infertile women.
CLINICAL UPDATE - BIOTIN DEFICIENCY IMPAIRS CARBOHYDRATE METABOLISM
Researchers found that biotin deficiency negatively alters carbohydrate metabolism. Specifically, biotin deficiency resulted in an impaired glucose and insulin tolerance test, suggesting “defects in insulin sensitivity,” according to the authors.
(Journal of Nutritional Biochemistry, April 2012)
LINK to ABSTRACT Effects of biotin deficiency on pancreatic islet morphology, insulin sensitivity and glucose homeostasis.