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October 2009 - Volume 3, Issue 10
In this issue...
- Carnitine therapy reduces hypertension
- Vitamin D deficiency increases risk of anemia
- Glutathione depletion common in celiac patients
- Homocysteine hurts telomeres while HDL helps them
- Low antioxidant status increases the risk of pre-eclampsia
CLINICAL UPDATE - Carnitine therapy reduces hypertension
32 non-diabetic patients with increased cardiovascular risk were given oral acetyl-L-carnitine twice daily for 24 weeks. The carnitine therapy safely reduced hypertension, insulin resistance and glucose tolerance.
(Hypertension, September 2009)
LINK to ABSTRACT: Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapy.
CLINICAL UPDATE - Vitamin D deficiency increases risk of anemia
Vitamin D and hemoglobin levels were measured on 554 people. An association was found between vitamin D deficiency and risk of anemia, supporting the hypothesis that vitamin D plays a role in the production of red blood cells.
(Annals of Hematology, September 2009)
LINK to ABSTRACT: Vitamin D deficiency and anemia: a cross-sectional study.
CLINICAL UPDATE - glutathione depletion common in celiac patients
Intestinal biopsies of 39 pediatric celiac patients were compared to 19 control patients and researchers found that glutathione-based antioxidant capacity was significantly reduced in the celiac patients.
(Clinical Biochemistry, September 2009)
LINK to ABSTRACT: Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease.
LINICAL UPDATE - Homocysteine hurts telomeres while hdl helps them
A study on the telomeres of 90 adults demonstrated a significant inverse correlation between telomere length and homocysteine in men. Similarly, in a study on over 650 adults, slower telomere shortening was observed in those with high levels of HDL cholesterol.
(Rejuvenation Research, September 2009)
(Atherosclerosis, August 2009)
LINK to ABSTRACT: Telomere Length in Lymphocytes of Older South Australian Men May Be Inversely Associated with Plasma Homocysteine.
LINK to ABSTRACT: Leukocyte telomere length is associated with HDL cholesterol levels: The Bogalusa heart study.
CLINICAL UPDATE - low antioxidant status increases risk of pre-eclampsia
A review of studies from 1986-2007 concluded that patients with documented cases of pre-eclampsia typically have lower levels of vitamins E and C as well as higher lipid peroxidation markers.
(Obstetrical & Gynecological Survey, September 2009)
LINK to ABSTRACT: Lipid peroxidation and antioxidant status in preeclampsia: a systematic review.
