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MTHFR POLYMORPHISM
(5,10-methylenetetrahydroreductase polymorphism)
See also GENE EXPRESSION, HOMOCYSTEINE, FOLATE, VITAMIN B6 and VITAMIN B12
2011 Am J Clin Nutr
MTHFR 677C->T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation.
2011 Eur J Clin Nutr
Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype.
2011 J Nutr
Methylenetetrahydrofolate Reductase Variants That Associate with Hypertension and Cardiovascular Disease Interact with Dietary Polyunsaturated Fatty Acids to Modulate Plasma Homocysteine in Puerto Rican Adults.
2011 J Nutr
Nutritional genomics: defining the dietary requirement and effects of choline.
2011 J Nutr
Polymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans.
2010 Braz J Med Biol Res
Genetics of homocysteine metabolism and associated disorders.
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2010 Clin Drug Investig
Associations between the C677T and A1298C polymorphisms of MTHFR and the efficacy and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis.
2010 Headache
MTHFR 677C>T and ACE D/I polymorphisms in migraine: a systematic review and meta-analysis.
2010 J Epidemiol
Genetic polymorphisms in homocysteine metabolism and response to folate intake: a comprehensive strategy to elucidate useful genetic information.
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2010 J Sex Med
Treatment of erectile dysfunction due to C677T mutation of the MTHFR gene with vitamin B6 and folic acid in patients non responders to PDE5i.
2010 Proc Nutr Soc
Postgraduate Symposium: The MTHFR C677T polymorphism, B-vitamins and blood pressure.
2009 J Nutr
Telomere Length in Peripheral Blood Mononuclear Cells Is Associated with Folate Status in Men.
2009 J Rheumatol
Metaanalysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity.
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2009 Pharmacogenet Genomics
The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability.
2009 Rinsho Byori
Bone quality markers: pentosidine, homocysteine, and MTHFR polymorphism
2008 Alt Med Rev
The methylation, neurotransmitter, and antioxidant connections between folate and depression.
2008 J Cell Mol Med
One carbon metabolism disturbances and the C667T MTHFR gene polymorphism in children with autism spectrum disorders.
2008 J Nutr Biochem
Folate intake and the MTHFR C677T genotype influence choline status in young Mexican American women
2008 J Pediatr
Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors.
2007 Headache
Efficacy of folic acid in children with migraine, hyperhomocysteinemia and MTHFR polymorphisms
2007 J Mol Diagn
Improved real-time multiplex polymerase chain reaction detection of methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C polymorphisms using nearest neighbor model-based probe design.
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2006 Cancer Res
Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c.
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2005 Circulation
Cardiology patient pages. Homocysteine and MTHFR mutations: relation to thrombosis and coronary artery disease.
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2005 Clin Gastroenterol Hepatol
Prevalence of hyperhomocysteinemia in adult gluten-sensitive enteropathy at diagnosis: role of B12, folate, and genetics.
2005 J Assist Reprod Genet
MTHFR C677T polymorphism associates with unexplained infertile male factors.
2004 J Clin Oncol
DNA methylation and cancer.
2003 Arch Gen Psychiatry
Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study
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2002 Pharmacogenetics
Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses.
1999 Proc Natl Acad Sci USA
Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults.
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1997 Cancer Res
Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.
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1996 Am J Hum Genet
Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.
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